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Fernandez, C. , Lieberman, R. and MOller, G.: The immune response to alpha 1-6
epitope of dextran is determined by a gene Buy Vibramycin Online linked to the IgCH locus. Scand .
J. Immunol . 10: 77, 1979.
Bona, C. , Mond, J.H., Stein, K.E., House, S., Lieberman, R. and Paul, W.E.:
Immune response to levan. Vibramycin For Acne III. The capacity to produce Vibramycin Cost anti-inulin anti-
bodies and cross-reactive idiotypes appears late in ontogeny. J. Immunol .
123: 1484, 1979.
Stein, K.E. , Bona, C, Lieberman, R. , Chien, C.C. and Paul, W.E.: Regulation
of the anti-inulin antibody response by a non-allotype-1 inked gene. J. Exp .
Med . 151: 1088, 1980.
Lieberman, R. , Rudikoff, S., Humphrey, Purchase Vibramycin Online W,, Jr. and Potter, M.: Allelic
forms of anti -phosphoryl choline antibodies. J. Vibramycin Hyclate Immunol . Submitted for
SMITHSONIAN SCIENCE INFORMATION EXCHANGE
PROJECT NUMBER (Oo NOT use this space)
U.S. DEPARTMENT OF
HEALTH, EDUCATION, AND WELFARE
PUBLIC HEALTH SERVICE
INTRAMURAL RESEARCH PROJECT
ZOl-AI Vibramycin 50mg -00038-08 LI
October 1, 1979 - September 30, 1980
TITLE OF PROJECT (80 characters or less)
Structure and Activity Studies on Immunologically Important Cells
and Generic Vibramycin Proteins
NAMES, LABORATORY AND INSTITUTE AFFILIATIONS, AND TITLES OF Vibramycin Suspension PRINCIPAL INVESTIGATORS AND ALL OTHER
PROFESSIONAL PERSONNEL ENGAGED ON THE PROJECT
Principal Investigator : Myron J. Waxdal, Ph.D., Sr. Investigator, LI/NIAID
Other Investigators : Dr. S. Toyoshima, LI/NIAID
Dr. B. Tyran. LI/NIAID
Dr. T. Basham, Order Vibramycin LI/NIAID
Dr. B. Mathieson, LMI/NIAID
Ms. B. Fovrflkes, LMI/NIAID
Ms. Vibramycin Antibiotics S. Vibramycin Antibiotic Sharrow, I/NCI
Dr. J. Axel rod, LCM/NIMH
Dr. F. Hi rata, LCM/NIMH
Dr. F. Finkelman, USUHS
COOPERATING UNITS (if any) y^^f^^g^j Services University of Health Sciences,
Bethesda, MD 20014
Laboratory of Immunology
SECT I ON
INSTITUTE AND LOCATION National Institute of Allergy and Infectious Diseases,
National Institutes nf .Health. Rethesda, MD,?n?ns
CHECK APPROPRIATE BOX(ES)
n (a) HUMAN SUBJECTS
n (al) MINORS □ (a2) INTERVIEWS
(b) HUMAN TISSUES
n (c) NEITHER
SUMMARY OF WORK (200 words or less - underline keywords)
An understanding of the mechanisms by which l ymphoid cells transfer in-
formation sj^nal^ are the major goals of this project. These include the
transfer of controlling or modulating signals between lymphocytes and also the
biochemical pathways by which signals from outside the cell are Vibramycin Doxycycline Hyclate transmitted past
the cell membrane ; from the receptors on the cell surface, passing thru the
lipid bi layer, and finally redirecting the internal metabolism of the cell. The
first of these studies extends our initial observations with a series of helper
factors (LSF) produced by T and thymus cells in response to Pa-2 activation
The Vibramycin Mg second extends our studies on membrane phospholipid methyl ati on Vibramycin Acne in response
to Con A stimulation.
To facilitate these studies we are also seeking to identify and fractionate
subpopulations of lymphoid cellS: both the producers of each LSF and the targets
of these intracellular signals. This is an extension of Buy Cheap Vibramycin our studies of differ-
ential lectin bindina to cells.
ZOl-AI -00038-08 LI
Intracellular Coirinunication via Soluble Factors
Murine lymphocytes were stimulated with the pokeweed Vibramycin Indications mitogen Pa-2,
washed and placed Vibramycin Online in culture in the absence of added mitogen. Cell free
supernatants were harvested at various times and assayed for their ability to
stimulate DNA synthesis and the formation of IgM secreting cells. Order Vibramycin Online DNA
synthesis was measured by thymidine incorporation and IgM secreting cells by
a modification of the reverse plaque technique. Six separate fractions have
been obtained, one of which appears to stimulate B cells in the absence of T
This year Vibramycin Syrup our efforts have been directed at further purification and
characterization of these LSF. An important finding was that LSF produced
by murine thymus or splenic T cells is able to stimulate Vibramycin Tablets both DNA synthesis
and immunoglobulin production by cultures of human peripheral lymphocytes. In
identifying the subset of cells that produce LSF, Pa-2 has been successfully
used to isolate the small (approximately 7%) subpopulation of thymocytes that
produce LSF in response to this mitogen. It was also found that the murine
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